Pyruvate Kinase Deficiency (PKD)
PKD affects a Labradors red blood cells
Pyruvate Kinase (PK) is an enzyme that plays an important role in energy generation and its deficiency impairs the red blood cells’ ability to metabolize, which in turn may cause anaemia and other blood-related issues.
(PKD is also used to denote Polycystic kidney disease which is a rare genetic kidney condition affecting Persian cats and some breeds of terrier. It is not known to affect Labradors)
Symptoms include :
- Muscle wasting
- Pale mucous membranes
- Elevated heart rate (tachycardia)
- Inability to perform routine exercises
Also associated with PKD in dogs is myelofibrosis (bone marrow cancer) and osteosclerosis (increase in bone density)this, along with liver failure, is the major cause of death in affected dogs.
The life expectancy of affected dogs is considerably shortened and most die before 4 years of age.
Testing for PKD.
As with most genetically inherited conditions, it is a faulty gene that causes PKD in dogs. DNA screening tests identify both affected and carrier dogs.
Prevention of PKD
If one parent is normal and another is a carrier, the pups will not be affected but some will be carriers. To help eradicate PKD it is best to ensure both parents are clear.
How single gene conditions are inherited
|Clear||Carrier||⇒||50% Clear + 50% Carriers|
|Carrier||Clear||⇒||50% Clear + 50% Carriers|
|Carrier||Carrier||⇒||25% Clear + 25% Affected + 50% Carriers|
|Carrier||Affected||⇒||50% Carriers + 50% Affected|
|Affected||Carrier||⇒||50% Carriers + 50% Affected|