Labrador Muscular Myopathy
Centronuclear myopathy (CNM) in Labradors is known as HMLR (hereditary myopathy of the Labrador Retriever) or more commonly Labrador muscular myopathy, it is a naturally occurring genetically inherited muscular disease in Labradors.
At birth, affected puppies are indistinguishable from their litter-mates, from two weeks of age a progressive significant weight loss is observed.
At one month the absence of tendon reflexes is noticed, at between 2 to 5 months the pup develops an awkward gait, a decreased exercise tolerance and difficulty in eating associated with generalized muscle weakness.
The pup will never recover from this disabling disease.
The genetic mutation for CNM was discovered by a team at Ecole Nationale Vétérinaire d’Alfort (Enva) in France.
Testing for CNM.
DNA screening tests to identify both affected and carrier dogs is available.
Prevention of CNM
As in PRSA & PKD If one parent is normal and another is a carrier, the pups will not be affected but some will be carriers.
To help eradicate CNM it is best to ensure both parents are clear.